Neuraltus' Approach

Increased levels of inflammation in the central nervous system (neuroinflammation) can damage key receptors and neurons in the central nervous system. The recent understanding of the fundamental role inflammation and macrophage activation have on chronic neurodegenerative disease progression is the reason Neuraltus has focused on macrophages.

Mechanism of Action for NP001

NP001 converts pro-inflammatory (activated) macrophages, a type of white blood cell, to their anti-inflammatory state.  The active ingredient in NP001, purified chlorite, combines with taurine in the macrophage to change the inflammatory macrophage back to its normal state [Figure 1][i].

NP001 is an investigational therapy and the only highly purified, intravenous formulation of sodium chlorite, which is not comparable to oral sodium chlorite. Additional information about oral sodium chlorite, and the potentially dangerous and toxic side effects which may hasten disease progression, can be found in a warning from the FDA and ALSUntangled article. Neuraltus does not recommend the use of oral sodium chlorite.

For more information on Neuraltus’ Phase 2 results, visit our Clinical Data page. 


Figure 1

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[i] Schempp, et al. Chlorite-hemoprotein interaction as key role for the pharmacological activity of the chlorite-based drug WF10. 2001. Arzneimittelforschung. 2001;51(7):554-62. DOI: 10.1055/s-0031-1300079. https://www.ncbi.nlm.nih.gov/pubmed/11505786. Accessed August 2017.